Biomarkers allow early detection of pre-eclampsia

Measuring blood levels of two biomarkers - asymmetric dimethylarginine (ADMA) and homocysteine - might detect women at high risk of developing pre-eclampsia.

The authors measured levels of ADMA, homocysteine, vitamins B6, B12, and folic acid every month from 20 weeks or less of gestation until delivery in 252 women. ADMA inhibits nitric oxide synthase. This enzyme generates nitric oxide, which protects the vascular system. Homocysteine protects against free radicals and endothelial damage.

Ten and 39 patients developed mild and severe pre-eclampsia, respectively. The authors excluded the
24 women who experienced other pregnancy complications. The remaining women had a mean age and body mass index of 30.9 years and 27.21kg/m² respectively.